One obvious upgrade is the daily trip to Columbus, which was formerly unavailable. The Megabus will leave at 2:30 a.m. and 2:30 p.m. every day for Cbus (with return trips at 1:45 a.m./p.m.) and will take three hours on the nose.
Arrivals and departures will all be added at Erie, Pa., and Buffalo, N.Y. as well. If you're heading south, connections will be available to Knoxville and Chattanooga, Tenn., Lexington, Ky., and Atlanta. The trip to Atlanta, by the way, which takes 15-16 hours (barring delays) and costs about $50 on weekdays, is roughly 1/10 the cost of flying.